生物医学工程研究2009，Vol.28Issue(2)：100-103,4.
生物可降解材料PLGA90/10的体外降解特性及生物相容性
In-vitro Degradation of Poly (DL-lactic-co-glycolic acid) 90L/10G
摘要
Abstract
We assessed the in vitro degradation of poly(dl-lactic-co-glycolic acid) (PLGA)90L/10G, a biodegradable material. In vitro degradation characteristics were evaluated by measuring decrease in the mass loss of PLGA films and conducted at 37℃ in pH 7.4 phosphate buffered saline. The morphological changes of films surface during degradation were observed on a scanning electron microscopy.The viability of cells was determined by MTT method. PLGA90/10 was hydrophobic polymer and it showed surface erosion characteristics. High-molecular-weight PLGA degraded slowly in the 4 months of beginning; there was 10% mass loss in the 120th day and rapid mass loss after the 120th day. There was no difference on the cell viability between control group and PLGA group. Our study provides a basis for the development of a useful vehicle for locally administered drugs.关键词
聚乳酸乙醇酸共聚物(PLGA)/体外降解/降解速率/细胞毒性Key words
Poly (dl-lactic-co-glycolic)/in-vitro degradation/Degradation rate/Cytotoxicity分类
医药卫生引用本文复制引用
杨宁,李为民,李悦,张伟,刘巍,耿建强,邵群..生物可降解材料PLGA90/10的体外降解特性及生物相容性[J].生物医学工程研究,2009,28(2):100-103,4.基金项目
黑龙江省科技攻关项目(No. GB06C50101) （No. GB06C50101）
