第一军医大学学报2003，Vol.23Issue(10)：1002-1005,1108,5.
鼻咽癌放疗后遗症112例发病因素分析
Etiological analysis of the sequelae of radiotherapy for nasopharyngeal carcinoma: a follow-up study of 112 cases
闫卫平 1陈龙华 1许志新 1邓晓刚1
作者信息
- 1. 第一军医大学南方医院放疗科,广东,广州,510515
- 折叠
摘要
Abstract
Objective To explore the etiology of the sequelae of radiotherapy for nasopharyngeal carcinoma (NPC) so as tofmd the possible means for reducing or preventing its occurrence. Methods A total of 112 pathologically confirmed patientswith nasopharyngeal carcinoma, who had survived for 5 years following the radiotherapy, were included in this study.Sixty-four patients with the primary carcinoma in the nasopharyngeal region received radiotherapy with the radiation fieldcovering the bilateral anterior ear regions, and in the other 48 patients, adjuvent exposure of the anterior nasal region wasadministered. The metastases in the cervical lymph nodes were exposed to tangential radiation by 40 Gy X-ray followed byapproximately 20 Gy vertical electron beam exposure. Results Limited mouth-opening and dry mouth occurred mostly duringthe first 2 years after radiotherapy, and hearing loss in the first year. Neck fibrosis tended to increase with the time elapse afterthe therapy, and posterior cranial nerve damages showed no signs of time-related occurrence. It was found that the occurrenceof neck fibrosis, dry mouth and the nerve injuries did not obviously correlate with the dosage of X-ray exposure in the anteriorear regions, while limited mouth-opening and the hearing loss increased with the radiation dosage. The sequelae did not arisefrom different radiation field selection as adopted in this study. Conclusion The radiation dose should be controlled at around70 Gy for NPC treatment, and for carcinoma remnant in the nasopharyngeal region, additional dose in the cavity would beappropriate. When the X-ray dose of 65 Gy in the neck region fails to result in satisfactory recession of lymph node metastasis,comprehensive treatment involving multiple modalities should be considered.关键词
鼻咽肿瘤/放射疗法/后遗症Key words
nasopharyngeal neoplasms/radiotherapy/sequelae分类
医药卫生引用本文复制引用
闫卫平,陈龙华,许志新,邓晓刚..鼻咽癌放疗后遗症112例发病因素分析[J].第一军医大学学报,2003,23(10):1002-1005,1108,5.
