耳鼻咽喉-头颈外科2001，Vol.8Issue(2)：101-104,4.
涎腺腺样囊性癌中PCNA、P16和P27的表达及其临床意义
Expressions of proliferating cell nuclear antigen, P16and P27 in adenoid cystic carcinoma of salivary glands
李正江 1唐平章 1徐震纲 1赵清正 1周春晓 1林冬梅 1吕宁1
作者信息
- 1. 中国医学科学院中国协和医科大学肿瘤医院头颈外科
- 折叠
摘要
Abstract
Objective:To evaluate the clinical significance of expression of proliferation cell nuclear antigen(PCNA),P16 and P27genes in adenoid cystic carcinoma of salivary glands.Methods:The expressions of PCNA,P16and P27were detected by immunohistochemical staining (SP)in 55 patients with adenoid cystic carcinoma of salivary glands.Results:The higher and lower expressions of PCNA were 45.5%(19/55) and 65.5%(35/55) respectively;of P16 were 45.5%(25/55) and 54.5%(30/55)respectively.And the positive and negative expressions of P27 were 34.5%(19/55) and 65.5%(36/55),respectively.The correlation of expression of PCNA gene with local recurrence and tumor site showed significant (P=0.0317,P=0.0186);but the expression of P16was no any significant correlation in all of the variables.The expression of P27 was significant on the regional lymph node metastaisis (P=0.0083).When higher expression of P16was 45.5%(25/55),the P27positive expression was 56.0%(14/25),which showed a significant positive correlation (P=0.0025).Conclusion:In adenoid cystic carcinoma of salivary glands,the PCNA gene should be one of the biological target predicting local recurrence,and P27gene should be one of the biological target justifying regional lymph node metastasis.关键词
唾液腺肿瘤/腺癌/基因分类
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李正江,唐平章,徐震纲,赵清正,周春晓,林冬梅,吕宁..涎腺腺样囊性癌中PCNA、P16和P27的表达及其临床意义[J].耳鼻咽喉-头颈外科,2001,8(2):101-104,4.
