心脑血管病防治2001，Vol.1Issue(2)：10-12,3.
冠心病患者载脂蛋白AI基因多态性的研究
Studies on the association of apolipoprotein AI gene polymorphism with coronary heart disease
摘要
Abstract
Objective To explore the association of apolipoprotein AI(ApoAI)gene polymorphism with coronary heart disease(CHD).Methods Four hundred and Sixty two patients with CHD and 182 non-CHD as controls that were determined by coronary angiography.Polymerase chain reaction(PCR),MspI digestion,polyacrylamide gel electrophoresis,and silver staining were used for the detection of ApoAI genotype.Results The M1++ and M2++ genotypes were most common in patients with CHD and controls.There were no differences between two groups(p>0.05).The frequencies of the M1-,M2+- genotypes in CHD group were significantly higher than those of control group(p<0.025～0.005),and they increased linearly with the number of diseased vessels.The frequency of combination with two polymorphism(M1+-,M1--and M2+-)in CHD subgroups was higher than that of controls.Patients with three diseased vessels had significantly higher frequency of combination of two polymorphism than those with no diseased vessel and single vessel(p<0.05～0.025).Conclusions These results suggest that ApoAI gene polymorphism is involved in the occurrence and the severity of CHD.关键词
冠心病/载脂蛋白AI/多态性分类
医药卫生引用本文复制引用
刘生祥,DanidWilcken..冠心病患者载脂蛋白AI基因多态性的研究[J].心脑血管病防治,2001,1(2):10-12,3.
