中国临床药理学与治疗学2000，Vol.5Issue(1)：10-13,4.
地高辛抗血清对缺氧损伤心肌组织内源性地黄样因子和心肌细胞膜ATP酶活性的影响
Effect of anti-digoxin antiserum on endogenous digitalis-like factor and membrane ATPase activity in hypoxic injury myocardium
摘要
Abstract
To evaluate the protective effect of anti-digoxin antiserum on hypoxic injury myocardium and its mechanism.Methods It was observed that different concentration anti-digoxin antiserum effect on endogenous digitalis-like factor and cell membrane ATPase activity in hypoxic myocardium model.Results The level of endogenous digitalis-like factor was remarkably higher,cell membrane ATPase activity were remarkably lower in hypoxic group than those of normal group;anti-digoxin antiserum can resume membrane ATPase activity.Conclusion Rise of endogenous digitalis-like factor was basic of molecular biology of myocardial damage during myocardial hypoxia.Anti-digoxin antiserum has lightened myocardial injury and has protective effect on hypoxic myocardium by against effect of endogenous digitalis-like factor.关键词
心肌/缺氧/内源性洋地黄样因子/钠钾ATP酶/钙ATP酶/地高辛抗血清Key words
myocardium/hypoxic injury/endogenous digitalis-like factor/Na+-K+-ATPase/Ca2+-ATPase/anti-digoxin antiserum分类
医药卫生引用本文复制引用
柯永胜,杨浩,杨霆,程光华,汪佑霞..地高辛抗血清对缺氧损伤心肌组织内源性地黄样因子和心肌细胞膜ATP酶活性的影响[J].中国临床药理学与治疗学,2000,5(1):10-13,4.基金项目
Project supported by the Foundation of Anhui Education Committee,№ 99jl0219 （）
