解放军医学杂志2001，Vol.26Issue(2)：102-103,2.
七氟醚对成年大鼠血脑屏障通透性的影响
INFLUENCE OF SEVOFLURANE ON BLOOD-BRAIN BARRIER PERMEABILITY IN RATS
摘要
Abstract
To observe the influence of different concentrations of sevoflurane on blood-brain barrier permeability in rats, thirty adult male SD rats were randomly divided into three groups: control group (without general anesthetics), 1 MAC sevoflurane and 1.5 MAC sevoflurane groups (maintaining end-expiratory concentration to 2.2% and 3.3% respectively for 1 hour). Before the end of the experiment, 2% Evans′ blue dye (EB, 3ml/kg) was intravenously injected. The range and areas of EB staining on the surface and standardized serial coronal section of the brain were assessed. The brain was also observed under the light microscope and electron microscope. The results indicated that sevoflurane at both concentrations did not increase the permeability of BBB to EB and lanthanum, and there were no significant changes in morphological features of central nervous system after inhalation of sevoflurane.关键词
七氟醚/血脑屏障/通透性/大鼠分类
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王红,宋运琴,张志鉴,张宏..七氟醚对成年大鼠血脑屏障通透性的影响[J].解放军医学杂志,2001,26(2):102-103,2.
