安徽医科大学学报2001，Vol.36Issue(2)：102-104,3.
国产因卡磷酸钠对体外破骨细胞性骨吸收的作用
Inhibitory effects of domestic incadronate on osteoclastic bone resorption in vitro
摘要
Abstract
Objective To study the effects of domestic incadronate(ICD) on osteoclastic bone resorbing lacunae. Methods Rabbit's osteoclastes were coincubated with bone slices and microphotographed,microdensitometric scanned and analyzed by computer image analysis system. Results ICD (0.5，5 and 50 μmol/L) caused dose-dependent reduction in the number of osteoclastic bone resorbing lacunae. The inhibitory effect ICD (5 μmol/L) was more remarkable than that of aminopropanediphosphonate (APD). Both ICD and APD reduced the surface area of osteoclastic bone resorbing lacunae. The effect of ICD was stronger than that of APD. Conclusion ICD directly suppresses osteoclastic bone resorption and may be effective in osteoporosis.关键词
破骨细胞/骨质吸收分类
医药卫生引用本文复制引用
杨雁,陈敏珠..国产因卡磷酸钠对体外破骨细胞性骨吸收的作用[J].安徽医科大学学报,2001,36(2):102-104,3.基金项目
安徽省自然科学基金资助课题 （）
