中国临床药理学与治疗学2004，Vol.9Issue(9)：1030-1032,3.
孕酮和孕烯醇酮硫酸盐对东莨菪碱引起的小鼠记忆损伤的保护作用
Protective effects of progesterone and pregnenolone sulfate on memory impairment mice induced by scopolamine
摘要
Abstract
AIM: To investigate the protective effects of progesterone and pregnenolone sulfate on memory impairment mice induced by scopolamine. METHODS:Pharmacological model of amnesia in mice was induced by scopolamine. Memory result was evaluated by the stepthrough latency in the passive-avoidance task. RESULTS: Animals displayed marked decrease in the stepthrough latency after administration (scopolamine 1cantly decreased performance of animals in the passiveavoidance task. CONCLUSION: Progesterone and pregnenolone sulfate can ameliorate the memory deficit.关键词
孕酮/孕烯醇酮硫酸盐/东莨菪碱/记忆/被动避暗试验Key words
progesterone/pregnenolone sulfate/scopolamine/memory/passive-avoidance task分类
医药卫生引用本文复制引用
王丹,于榕,鲁映青,姚明辉..孕酮和孕烯醇酮硫酸盐对东莨菪碱引起的小鼠记忆损伤的保护作用[J].中国临床药理学与治疗学,2004,9(9):1030-1032,3.基金项目
Project supported by Natural Science Foundation of Shanghai ( No02ZR14007 ) （ No02ZR14007 ）
