中国当代儿科杂志2005，Vol.7Issue(2)：103-106,4.
尿8-异前列腺素F2α测定在新生儿缺氧缺血性脑病病情评估中的价值
Value of urine 8-iso-PGF2α in the assessment of the severity of neonatal hypoxic-ischemic encephalopathy
摘要
Abstract
Objective It was aimed to determine the concentration of urine 8-iso-PGF2α in normal neonates and neonates with hypoxic-ischemic encephalopathy (HIE) and to study the value of urine 8-iso-PGF2α in the assessment of the severity of neonatal HIE. Methods Urine samples from normal (n = 126) and HIE ( n = 151 ) neonates were collected on the 1 st, 3rd and 7th days after birth. ELISA was used to determine the urine 8-iso-PGF2α contents. Results 1 ) Urine 8-and 7th days after birth, respectively. There was no significant difference among the three days for the urine 8-iso-PGF2α contents. 2) On the 1 st day of HIE onset, neonates with mild, moderate and severe HIE had higher levels of urine 8-isoneonates (P < 0. 001 ). 3 ) On the 3rd day, the urine 8-iso-PGF2α content in neonates with moderate and severe HIE while that of the neonates with mild HIE regressed to normal. 4) On the 7th day, there was no significant difference in the of urine 8-iso-PGF2α were defined to distinguish from normal to mild HIE, from mild to moderate HIE and from moderate to severe HIE. As defined, the corresponding sensitivity and specificity were 95.2% and 99.2%, 100% and 95.2%,65.8% and 100%. Conclusions The urine 8-iso-PGF2α levels in neonates were stable within 7 days after birth. The urine 8-iso-PGF2α contents in HIE neonates reached the peak within 24 hours after onset. There was a correlation between the urine 8-iso-PGF2α contents and the severity of HIE, suggesting that urine 8-iso-PGF2α may be a reliable and convenient index for the assessment of the severity of HIE.关键词
8-异前列腺素F2α,尿/缺氧缺血,脑/婴儿,新生Key words
8-iso-PGF2α, urine/Hypoxia-ischemia, brain/Infant, newborn分类
医药卫生引用本文复制引用
陈玲玲,肖昕,熊爱华,陈文清,周晓光,叶贞志..尿8-异前列腺素F2α测定在新生儿缺氧缺血性脑病病情评估中的价值[J].中国当代儿科杂志,2005,7(2):103-106,4.基金项目
Guangzhou Scientific Foundation of grant (No. A2004717). （No. A2004717）
