四川医学2009，Vol.30Issue(7)：1032-1034,3.
胰岛素类似物和重组人胰岛素强化治疗糖尿病观察
To observe and compare the effect of glycemic control in intensively treated adult subject with type 2 diabetes using insulin analogs and gene recombine human insulin
鲜杨 1李蓬秋 1陈树 1张学军 1吴冀川 1包明晶 1杨艳 1张磊 1朱显军1
作者信息
- 1. 四川省人民医院内分泌科,干部科,四川成都,610072
- 折叠
摘要
Abstract
Objective The study was designed to evaluate the clinical effectiveness and safety of glycose control using insulin analogs or gene recombine human insulin intensively treated adult subject with type 2 diabetes inadequately controlled with oral antidiabetes drugs. Methods This was 9 months open label randomized control trial involving 45 type 2 diabetes that needed using insulin assigned into two groups either using insulin analogs group or gene recombine human insulin group. Rapid-act insu-lin analogs lispro insulin or human regular insulin before each med plus long-act insulin analogs glargine or NPH insulin at bed-time was given subcutaneous injection quartic week respectively. Patients monitor blood glucose week by themselves, A1C was de-termine quarterly. Results Baseline A1C, diabetes duration and demography was similar in two groups. Mean A1C was significant-ly decreased insulin analogs group (-2.89±0.054)% ; recombine human insulin group (-2.32±0.052)% (P<0.05). Insulin analogs group showed superiority in A1C improvement (-0.57% ;P<0.01). A significantly higher number of subjects achieved Alc≤6.5% (52.17%vs 27.27%) and within target range was higher in the insulin analogs group(73.91% vs 45.45% ). Insulin does was similar, body weight was not significant differences between the two groups. Above target range glycemia were lower in the insulin analogs group. Nocturnal and severe hypoglycemia were lower in the insulin analogs group. Conclusion Our result shows that improved glycemic control can be gained and maintained over 9 months in patients with type 2 diabeties by using insulin analogs with no differece in dose and weight gain.关键词
糖尿病/胰岛素/胰岛素类似物Key words
diabetes/ insulin analogs/ intension treatment分类
医药卫生引用本文复制引用
鲜杨,李蓬秋,陈树,张学军,吴冀川,包明晶,杨艳,张磊,朱显军..胰岛素类似物和重组人胰岛素强化治疗糖尿病观察[J].四川医学,2009,30(7):1032-1034,3.
