中华医学杂志（英文版）2009，Vol.122Issue(9)：1032-1038,7.DOI:10.3760/cma.j.issn.0366-6999.2009.09.006
Population pharmacokinetics of remifentanil in patients undergoing orthotopic liver transplantation
Population pharmacokinetics of remifentanil in patients undergoing orthotopic liver transplantation
ZHANG Li-ping 1YANG Lu 1BI Shan-shan 2LU Wei 2ZHANG Xian-hua 3ZHAI Suo-di 3DUAN Li-ping4
作者信息
- 1. Department of Anesthesiology Peking University Third Hospital Beijing 100191, China
- 2. School of Pharmaceutical Sciences, Peking University, Beijing 100191, China
- 3. Department of Pharmacy Peking University Third Hospital Beijing 100191, China
- 4. Department of Gastroenterology Peking University Third Hospital Beijing 100191, China
- 折叠
摘要
Abstract
Backgroud Little is known about the influence of liver transplantation on the pharmacokinetics of most anesthetic drugs. The goal of this study was to study the population pharmacokinetics of remifentanil in the different phases of orthotopic liver transplantation (OLT) and the influence of relevant factors.Methods Thirteen adult patients undergoing OLT were enrolled. A single bolus infusion of remifentanil 5 μg/kg was administered during the preanhepatic, anhepatic and neohepatic phases of OLT. Arterial blood samples of 1.5 ml were collected at 0 (baseline), 1, 2, 3, 5, 7, 10, 15, 20, 25, 30, 45, 60 and 90 minutes after drug administration. Remifentanil concentration was assayed by high-performance liquid chromatography/mass spectrometry/mass spectrometry (HPLC/MS/MS). Population pharmacokinetic modeling was performed using nonlinear mixed-effects modeling (NONMEM).Results The pharmacokinetics of remifentanil in patients undergoing OLT was best described by a two-compartment open model. The pharmacokinetic parameters were not influenced by age, gender, operative phase, blood temperature, rehydration volume, or blood loss volume during sampling. The volume of distribution in the central compartment (V1) and the volume of distribution in the peripheral compartment (V2) were influenced by body weight. Conclusions The population pharmacokinetics of remifentanil in patients undergoing OLT can be well described by a two-compartment open model. The functional status of the liver does not significantly affect the pharmacokinetics of remifentanil, but the body weight is an influential factor of V1 and V2.关键词
remifentanil/liver transplantation/pharmacokinetics/anesthesiaKey words
remifentanil/liver transplantation/pharmacokinetics/anesthesia分类
医药卫生引用本文复制引用
ZHANG Li-ping,YANG Lu,BI Shan-shan,LU Wei,ZHANG Xian-hua,ZHAI Suo-di,DUAN Li-ping..Population pharmacokinetics of remifentanil in patients undergoing orthotopic liver transplantation[J].中华医学杂志（英文版）,2009,122(9):1032-1038,7.
