解放军医学杂志2001，Vol.26Issue(2)：104-106,3.
次声作用后鼠脑CA1区mGluR1α表达改变及其拮抗剂MCPG的作用研究
THE CHANGE IN mGluR1α IN CA1 AFTER INFRASONIC DAMAGE AND THE EFFECT OF ITS ANTAGONIST MCPG
李志刚 1费舟 1章翔 1贾克勇 1陈景藻 1贺晓生 1刘先珍1
作者信息
摘要
Abstract
To study the change in mGluR1α in CA1 after infrasonic damage and the effect of its antagonist MCPG,120 SD rats were randomizied into infrasonic damage group and MCPG therapy group.The two groups were subdivided into control group and 1-challenge, 7-chellenges, 14-challenge groups respectively,each group consisted of 15 rats. Rats were exposed to 8Hz 130dB infrasound as designed,2h for each challenge.The mGluR1α was stained by immunohistochemistry method.The changes in mGluR1α and cell pattern were observed under light and electronic microscopes.The results showed the number of mGluR1α positive neurons increased after 1-challenge infrasonic damage(P＜0.05)；and in the 7-challenge group was most obvious(P＜0.01)；in the 14-challenge group,it decreased to normal level.The change of mGluR1α in MCPG therapy groups was as that in infrasonic damage groups(P＞0.05).MCPG had an effect to protect neuron from infrasonic damage as identified by morphology.It is concluded that the change of mGluR1α activity could mediate excitotoxicity and was one of the major factors related with neuron injury after infrasound.关键词
次声/mGluR1α/脑损伤/MCPG分类
医药卫生引用本文复制引用
李志刚,费舟,章翔,贾克勇,陈景藻,贺晓生,刘先珍..次声作用后鼠脑CA1区mGluR1α表达改变及其拮抗剂MCPG的作用研究[J].解放军医学杂志,2001,26(2):104-106,3.
