生物医学工程研究2009，Vol.28Issue(2)：104-107,4.
交联透明质酸凝胶膜的制备及其生物相容性的研究
Preparation and Biocompatibility Investigation of the Cross-linked Hyaluronic Gel Film
陈建英 1宋海波 2贺艳丽 1刘杰1
作者信息
- 1. 山东省生物药物研究院,济南,250101
- 2. 山东省医药工业研究所,济南,250100
- 折叠
摘要
Abstract
To prepare and evaluate the biocompatibility of the cross-linked hyaluronic gel film, the studies on its cytotoxicity and hemolysis in vitro, acute systemic toxicity, eye stimulation, subcutaneous reactivity,sensitization and genotoxicity of the gel film were executed in compliance with the methods described in GB/T 16886. The experimental results showed that the gel film had no hemolysis,no acute systemic toxicity,no eye irritation,no subcutaneous reactivity,no sensitization, cytotoxicity was scored 0～1 grade. The negative results in Ames test, mammalian cell chromosome aberration and micronucleus test demonstrated that the gel film had no genotoxicity. It's concluded that the cross-linked hyaluronic gel film has reliable biocompatibility and maybe an ideal biomedical material.关键词
交联透明质酸凝胶/制备/生物相容性/毒性Key words
Cross-linked hyaluronic gel/Preparation/Biocompatibility/Toxicity分类
医药卫生引用本文复制引用
陈建英,宋海波,贺艳丽,刘杰..交联透明质酸凝胶膜的制备及其生物相容性的研究[J].生物医学工程研究,2009,28(2):104-107,4.
