中国中西医结合杂志2001，Vol.21Issue(2)：105-107,3.
刺五加注射液对早期糖尿病肾脏病变及血浆、尿内皮素的影响
Effect of Acanthopanax Senticosus Injection on Plasma and Urinary Endothelin in Early Stage of Diabetic Nephropathy
倪海祥 1罗苏生 1邵国民 1魏佳平 1姚定国 1郑翠瑛1
作者信息
- 1. 浙江省中医院内分泌科(杭州310006)
- 折叠
摘要
Abstract
Objective: To explore the mechanism of Acanthopanax senticosus(AS) on diabetic nephropathy (DN) patients by observing its effect on urinary albumin excretion (UAE) and renal endothelin (ET) metabolism. Methods: Forty-seven patients of diabetes mellitus (DM) type 2 with persistent microalbuminuria and normotension were randomly divided into two groups, the conventional treatment group (control group) and the AS treatment group. The treatment course was 8 weeks. The changes of UAE, plasma and urinary ET levels before and after treatment were observed. Results: Levels of UAE, plasma and urinary ET lowered significantly (P＜0.01) in the AS groups, while no significant change was shown in the control group. By correlation analysis, the decrement of UAE was positively correlated with the decrement of urinary and plasma ET levels (r＝0.72，P＜0.01 and r＝0.63，P＜0.01). Conclusion: The protective effect of AS injection on DN is probably correlated with its inhibition on ET synthesis in kidney.关键词
糖尿病肾病/刺五加/内皮素分类
医药卫生引用本文复制引用
倪海祥,罗苏生,邵国民,魏佳平,姚定国,郑翠瑛..刺五加注射液对早期糖尿病肾脏病变及血浆、尿内皮素的影响[J].中国中西医结合杂志,2001,21(2):105-107,3.
