中德临床肿瘤学杂志（英文版）2005，Vol.4Issue(2)：105-107,3.
凋亡阳性率及凋亡相关蛋白Bcl-2、bax在宫颈癌放疗前后表达的意义
The Expression of Apoptosis-Related Genes Bcl-2 and Bax Protein and Apoptosis Positivity in Cervical Carcinoma during Irradiation
赵东利 1石景森 1李明众 1宋丽萍 1王书文1
作者信息
- 1. 西安交通大学第一医院肿瘤放疗科,710061
- 折叠
摘要
Abstract
Objective: To evaluate the apoptosis positivity, the expression of Bcl-2, bax proteins in 30patients with squamous cell cervix carcinoma before and after radiotherapy. Methods: By using immunohistochemical and TDT-dUTP nick end labelling techniques, 30 cases of squamous cell cervical carcinoma were analyzed. Results: The apoptosis positivity before and after irradiation was 76.7% and 100% respectively, with the difference being significant (P＜0.05); The positive rates of Bcl-2 protein before and after irradiation were 73.3% and 46.7% respectively, with the difference being significant (P＜0.05); The positive rates of bax protein before and after irradiation were 86% and 100% respectively, with the difference being significant (P＜0.05). Conclusion: bax and Bcl-2 protein play an important role in apoptosis induced by fractionated radiation therapy. Apoptosis induced by irradiation is contributed to upregulation of bax protein or downregulation of Bcl-2 protein.关键词
宫颈癌/放疗/凋亡阳性率/Bcl-2蛋白/bax蛋白Key words
cervical carcinoma/radiotherapy/apoptosis positivity/Bcl-2 protein/bax protein引用本文复制引用
赵东利,石景森,李明众,宋丽萍,王书文..凋亡阳性率及凋亡相关蛋白Bcl-2、bax在宫颈癌放疗前后表达的意义[J].中德临床肿瘤学杂志（英文版）,2005,4(2):105-107,3.
