山西医科大学学报2008，Vol.39Issue(12)：1057-1060,4.
乙酰胆碱对大鼠齿状回成年神经发生的作用观察
Acetylcholine regulates adult neurogenesis in rat's DG
摘要
Abstract
Objective To observe the effects of acetylcholine(ACh)on adult neurogenesis in dentate gyrus(DG)of rats. Methods ACh was injected stereotaxically into the lateral ventricles of male rats in treated group,0.9% NaCl saline was injected in sham group,while the rats in control group were only anaesthetized. Immunohistochemistry was used to calculate the numbers of BrdU+and BrdU+/CaBP+ new born granule neurons in DG. Results The numbers of the BrdU+ and BrdU+/CaBP+ labeled cells in treated group were significandy higher(637.00 ± 39.50 and 491.00 ± 47.29 per hippoeampi, N = 3, n = 36) than in sham group (339.00±17.62 and 305.00±17.62 per hippocampi,N = 3, n = 36,P<0.05)and in control grip(336.00 ± 49.05 and 304.00± 30.44 per hippocampi, N = 3, n = 36, P < 0.05), respectively, but there was no statistical difference between sham group and control group(P >0.05). Conclusion These results indicate that ACh could promote the adult neurogenesis in DG and thus facilitate the learning and spatial memory.关键词
成年神经发生/乙酰胆碱/齿状回/大鼠Key words
adult neurogenesis/ acetylcholine/ dentate gyrus/ rats分类
医药卫生引用本文复制引用
张文平,仇玉兰,郑金平,张策..乙酰胆碱对大鼠齿状回成年神经发生的作用观察[J].山西医科大学学报,2008,39(12):1057-1060,4.基金项目
山西省回国留学人员基金资助项目(2007-40) （2007-40）
