中华医学杂志（英文版）2006，Vol.119Issue(13)：1059-1064,6.
A comparison of angiographic and clinical outcomes after sirolimus-eluting versus paclitaxel-eluting stents for the treatment of in-stent restenosis
A comparison of angiographic and clinical outcomes after sirolimus-eluting versus paclitaxel-eluting stents for the treatment of in-stent restenosis
LI Jian-jun 1WU Yong-jian 1YUAN Jin-qing 1CHEN Jue 1YOU Shi-jie 1DAI Jun 1XIA Ran 1GAO Run-lin 1XU Bo 1YANG Yue-jin 1MA Wei-hua 1CHEN Ji-lin 1QIAO Shu-bing 1QIN Xue-wen 1YAO Min 1LIU Hai-bo1
作者信息
- 1. Department of Cardiology, Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100037,China
- 折叠
摘要
Abstract
Background In-stent restenosis (ISR) remains a challenge for interventional cardiologists. Some data suggest that drug-eluting stents (DES) represent a promising new option for the treatment of patients with ISR. Currently,2 DES platforms are available [sirolimus-eluting stents (SES) and paclitaxel-eluting stents (PES) ], but the superiority of either approach for treating ISR has not been convincingly demonstrated. The aim of the present study was to retrospectively compare angiographic and clinical outcomes after treatment of ISR with SES or PES in a series of consecutive patients with ISR.Methods A total of 745 consecutive patients were treated with bare metal stents from April 12, 2004 to December 31, 2004 in our center. Of these, clinically driven target lesion revascularization (TLR) was performed in 54 ISR from 54 patients at 7 months. Of the 54 patients with ISR, 36 received SES and 18 received PES.Follow-up included angiography and assessment of clinical outcome, both performed 7 months after DES implantation.Results There were no significant differences in baseline clinical data (including medication usage and lesion characteristics) between the two groups. Except for overlapping of multiple stents, procedural parameters were also similar in both groups. Seven-month angiographic follow-up showed that the binary restenosis rate was higher in patients treated with PES than that in patients treated with SES (in-stent binary restenosis: 27.8% vs 5.6%, P＜0.023; In-segment binary restenosis: 44.4% vs 13.9%, P＜0.014). Major adverse cardiac events (MACE)occuring during hospitalization or during the follow-up period including thrombosis and TLR was similar in both groups (22.2% vs 8.3%, P＞0.05).Conclusions Results from this small sample size, retrospective, single-center study showed that SES might be superior to PES in treating ISR because of lower 7-month restenosis rates (both in-stent and in-segment binary restenosis) with no increased incidence of MACE.关键词
coronary artery disease/drug-eluting stent/restenosis/angiographyKey words
coronary artery disease/drug-eluting stent/restenosis/angiography分类
医药卫生引用本文复制引用
LI Jian-jun,WU Yong-jian,YUAN Jin-qing,CHEN Jue,YOU Shi-jie,DAI Jun,XIA Ran ,GAO Run-lin,XU Bo,YANG Yue-jin,MA Wei-hua,CHEN Ji-lin,QIAO Shu-bing,QIN Xue-wen,YAO Min,LIU Hai-bo..A comparison of angiographic and clinical outcomes after sirolimus-eluting versus paclitaxel-eluting stents for the treatment of in-stent restenosis[J].中华医学杂志（英文版）,2006,119(13):1059-1064,6.
