南京医科大学学报(英文版)2003，Vol.17Issue(3)：106-109,4.
脑脊液中β-淀粉样蛋白检测与阿尔茨海默病的早期诊断
The Value of CSF Level of β-amyloid Protein in the Diagnosis of Alzheimer's Disease
摘要
Abstract
Objective:To evaluate the diagnostic potential of cerebrospinal fluid ( CSF) levels of β-amyloid protein (Aβ) as biochemical marker for senile dementia in clinical practice. Methods: Sensitive enzyme-linked immunosorbent assay ( ELISA) was performed in our laboratory to detect the CSF levels of Aβ1-40, Aβ1-42 in 54 patients with Alzheimer's disease (AD), and 30 normal controls (NC). Results: The cut off value of Aβ ratio and Aβ1-42 concentration in NC group provided 54. 51%, 90. 00% sensitivity and 81. 25%, 84. 38% specificity respectively in diagnosis of AD. Conclusion: AD group bad a significant decreased level of Aβ1-42 and an increased level of Aβ ratio, compared with NC group.关键词
阿尔茨海默病/脑脊液/β-淀粉样蛋白Key words
Alzheimer's disease/cerebrospinal fluid/β-amyloid protein分类
医药卫生引用本文复制引用
程虹,丁新生,王琨,张雪玲,王颖,姚娟,邓晓萱..脑脊液中β-淀粉样蛋白检测与阿尔茨海默病的早期诊断[J].南京医科大学学报(英文版),2003,17(3):106-109,4.基金项目
Supported by Grant from National Ministry of Personnel Foundation for Distinguished Young Scholars of China (1998) （1998）
