心理学报2003，Vol.35Issue(1)：106-111,6.
腺苷A2a受体介导利血平引起的行为性抑郁
ADENOSINE A2A RECEPTOR MEDIATES RESERPINE-INDUCED DEPRESSION IN RATS
黄庆军 1郝新玲 1ThomasRMinor2
作者信息
- 1. 白求恩军医学院心理神经免疫学实验室,石家庄,050081
- 2. 美国加州大学洛杉矶分校心理学系
- 折叠
摘要
Abstract
Intraperitoneal injection of reserpine (4, 6 or 8 mg/kg) increased floating time in the Porsolt swim test in a dose-and time-dependent manner in rats. Although such behavioral depression usually is attributed to drug-induced depletion of brain monoamines, the outcome might be more directly related to brain adenosine signaling associated neuronal overactivation or brain cytokine induction following excitotoxic tissue damage. We addressed these possibilities by pretreating rats with caffeine (7 mg/kg), a high affinity adenosine receptor antagonist, prior to reserpine treatment (6 mg/kg). Caffeine partially reversed the ensuing behavioral depression as measured in the Prosolt swim test conducted 1, 24 and 72 hours after reserpine treatment. Further investigation has also been done to determine the subtype of adenosine receptor, which should mediate reserpine's effect. The results showed that adenosine A2 receptor antagonist (DMPX) and A2a antagonist (CSC) reversed the reserpine-induced behavioral depression dose-dependently. These results suggest that adenosine mediates reserpine-induced depression via adenosine A2a receptor and provide evidence that adenosine plays a crucial role in mediating behavioral depression, which will benefit in understanding the mechanism of depression and finding new drug for anti-depressant treatment.关键词
利血平/行为性抑郁/腺苷Key words
reserpine/behavioral depression/adenosine/antagonist分类
社会科学引用本文复制引用
黄庆军,郝新玲,ThomasRMinor..腺苷A2a受体介导利血平引起的行为性抑郁[J].心理学报,2003,35(1):106-111,6.
