转化生长因子-β2在糖尿病大鼠视网膜中基因表达的研究OA
Gene expression of transforming growth factor-β2 in retina of diabetic rats
目的:糖尿病视网膜病变(diabetic retinophthy, DR)是糖尿病在眼部的主要并发症,为我国四大致盲眼病之一.DR的病理基础是微血管病变,研究其发生、发展的机理对预防和治疗这一疾病具有重要的临床意义.而转化生长因子-β(transforming growth factor-β, TGF-β)是一类能够调节细胞生长和分化的多肽,具有多种生物学作用.本研究选择转化生长因子-β2(TGF-β2)为研究对象,检测其在不同时相点糖尿病大鼠视…查看全部>>
AIM: To detect the gene expression of TGF-β2 in retinas of diabetic rats at different stages, to observe and analyze the effect of TGF-β2 on the retinas of diabetic rats, to explore the role of TGF-β2 in pathogenesis of diabetic retinopathy (DR), and to provide experiment data and experience for further clinic studies.METHODS: Sprague-Dawley (SD) rats were used and retinas were dissected. The total RNA was isolated from which the first strand of cDNA was pre…查看全部>>
沈炜;柳林
200433,中国上海市,第二军医大学附属长海医院眼科200433,中国上海市,第二军医大学附属长海医院眼科
医药卫生
转化生长因子-β2基因表达视网膜糖尿病大鼠逆转录聚合酶链反应
transforming growth factor-β2gene expressionretinadiabetic ratRT-PCR
《国际眼科杂志》 2008 (6)
TGF-β2/SMADs信号转导通路在糖尿病视网膜病变中的调控机制
1065-1069,5
中国国家自然科学基金资助项目(N0. 30271391)中国上海市卫生局科研项目(N0. 034124)中国上海市卫生系统百名跨世纪优秀学科带头人培养计划(百人计划)基金资助项目(N0. 057)National Natural Science Foundation of China (No. 30271391) Foundation of Scientific Research Program of Health Bureau of Shanghai City, China (No. 034124) Foundation of Training Plan for a hundred Transcentury Excellent Subject Leaders in Shanghai Public Health System, China (No. 057)
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