首页|期刊导航|东华大学学报（英文版）|Preparation and Characterization of Nimodipine-loaded Methoxy Poly (ethylene glycol)-poly (lactic acid) Diblock Copolymer Nanoparticles
东华大学学报（英文版）2006，Vol.23Issue(2)：107-114,8.
Preparation and Characterization of Nimodipine-loaded Methoxy Poly (ethylene glycol)-poly (lactic acid) Diblock Copolymer Nanoparticles
Preparation and Characterization of Nimodipine-loaded Methoxy Poly (ethylene glycol)-poly (lactic acid) Diblock Copolymer Nanoparticles
摘要
Abstract
Amphiphilic diblock copolymers, methoxy poly (ethylene glycol)-poly(lactic acid) (MePEG-PLA), were synthesized from monomers of DL-lactide and methoxy poly (ethylene glycol) by a ring opening bulk polymerization in the presence of stannous octoate. Their chemical structure and physical properties were investigated using FTIR, NMR, GPC, and fluorescence spectroscopy. To estimate the feasibility as colloidal drug carrier, nimodipine (ND) was loaded into MePEG-PLA block copolymer nanoparticles by phaseseparation/dialysis method. The mean diameter and drug loading efficiency of ND-loaded MePEG-PLA copolymer nanoparticles depended on PLA/MePEG block composition of the copolymer and drug/polymer feed ratio in preparation. NMR study confirmed that nimodipine was entrapped into the hydrophobic inner core of MePEG-PLA copolymer nanoparticles and hydrophilic PEG chains were located on the surface of the drug-loaded polymer nanoparticles. In vitro release experiments exhibited the sustained release behavior of nimodipine from MePEG-PLA copolymer nanoparticles, without any burst effect.关键词
colloidal nanoparticles/biodegradable/drug delivery system/diblock copolymer/nimodipineKey words
colloidal nanoparticles/biodegradable/drug delivery system/diblock copolymer/nimodipine分类
化学化工引用本文复制引用
ZHA Liu-sheng,LI Lan,ZHAO Hui-peng..Preparation and Characterization of Nimodipine-loaded Methoxy Poly (ethylene glycol)-poly (lactic acid) Diblock Copolymer Nanoparticles[J].东华大学学报（英文版）,2006,23(2):107-114,8.基金项目
The authors are grateful to the National Natural Science Foundation of China (no. 50573009 ) for its financial support. （no. 50573009 ）
