摘要
Abstract
Aim To study the change of heme oxygnease- 1(HO- 1) and endogenous carbon monoxide(CO) on hypoxia- ischemia brain damage(HIBD) in newborn rats and the therapeutic effect of the Znpp on HIBD.Method 7d SD rats were divided into control group,hypoxic- ischemia group(HI) and hypoxic- ischemia+ Znpp group(HI+ Znpp)at random.HO- 1 activity,cGMP level in the brain and carbon monoxide level in blood were observed respectively at 1,4,12 and 24 h after hypoxic- ischemia by using spectrophotometry etc.Results HO- 1 activity,CO and cGMP level of HI group were significant higher than those of control groups at 1,4,12 h(P< 0.01);In HI,neurons were damaged severely,Znpp could antagonize the about- mentioned pathological changes effectively.Conclusion In HIBD,the increased HO- 1 activity resulted in increase of endogenous CO that can enhance cGMP;Znpp may protect nerve cell from damage by preventing HO- 1 activity resulted in decrease of endogenous CO.HO- CO- cGMP system may play an important role in the pathogenesis of HIBD.
关键词
低氧-缺血,脑/模型,动物/一氧化碳/血红素氧化酶(脱环)Key words
hypoxia- ischemia brain/models,animal/carbon monoxide/heme oxygenase(decyclizing)分类
医药卫生
