首页|期刊导航|高技术通讯（英文版）|Study of the selective effect on cells induced by nanosecond pulsed electric field with the resistor-capacitor circuit model
高技术通讯（英文版）2009，Vol.15Issue(1)：108-114,7.DOI:10.3772/j.issn.1006-6748.2009.01.019
Study of the selective effect on cells induced by nanosecond pulsed electric field with the resistor-capacitor circuit model
Study of the selective effect on cells induced by nanosecond pulsed electric field with the resistor-capacitor circuit model
摘要
Abstract
A resistor-capacitor (RC) circuit model is proposed to study the effect of nanosecond pulsed electric field on cells according to the structure and electrical parameters of cells. After a nanosecond step field has been applied, the variation of voltages across cytomembrane and mitochondria membrane both in normal and in malignant cells are studied with this model. The time for selectively targeting the mitochondria membrane and malignant cell can be evaluated much easily with curves that show the variation of voltage across each membrane with time. Ramp field is the typical field applied in electrobiology. The voltages across each membrane induced by ramp field are analyzed with this model. To selectively target the mitochondria membrane, proper range of ramp slope is needed. It is relatively difficult to decide the range of a slope to selectively affect the malignant cell. Under some conditions, such a range even does not exist.关键词
electroporation/resistor-capacitor circuit model/nanosecond pulsed electric fieldKey words
electroporation/resistor-capacitor circuit model/nanosecond pulsed electric field分类
信息技术与安全科学引用本文复制引用
Xu Fei,Xiao Dengming,Li Zhaozhi..Study of the selective effect on cells induced by nanosecond pulsed electric field with the resistor-capacitor circuit model[J].高技术通讯（英文版）,2009,15(1):108-114,7.基金项目
Supported by National Natural Science Foundation of China (50477007). （50477007）
