临床医学工程2009，Vol.16Issue(7)：109-112,4.
前列腺素E2受体亚型EP2和EP4的最新研究进展
The Latest Progress in E-Prostanoid (EP) Receptor Subtypes EP2 and EP4
摘要
Abstract
Prostaglandin(PG)E2 exerts its physiological actions via four functionally antagonistic E-prostanoid (EP) receptors, which are designated as subtypes EP1, EP2, EP3 and EP4 respectively. The subtype EP3 has multiple mRNA splicing isoforms. All of these receptors are G-protein coupled receptors (GPCRs). The EP receptor subtypes exhibit different tissue distribution and expressional regulation, and mediate various signaling pathway and physiological functions. Among the 4 EP receptors, EP2 and EP4 are coupled to the same Goprotein (stimulate G-protein, Gs), and increase cellular cAMP level upon activation. EP2 and EP4 function redundantly in some physiological processes, while they play distinct roles in some other processes. In the current paper, the latest advances in study of EP2 and EP4 receptors will be summarized and discussed.关键词
前列腺素E2/EP2/EP4Key words
PGE2/EP2/EP4分类
医药卫生引用本文复制引用
朱森,杨吉春,管又飞..前列腺素E2受体亚型EP2和EP4的最新研究进展[J].临床医学工程,2009,16(7):109-112,4.基金项目
本课题受国家自然科学基金资助(项目编号:30670766,30870995). （项目编号:30670766,30870995）
