白求恩医科大学学报2001，Vol.27Issue(2)：111-113,3.
X射线对小鼠腹腔巨噬细胞表达B7-1和B7-2的影响
Effect of X-rays on the expression of B7-1 and B7-2 in per itoneal macrophages
摘要
Abstract
Objective: The effect of whole body irradiation (WBI) on B7-1 and B7-2 express ion in peritoneal macrophages in mice was observed.Methods:Immunohistochemistry (ABC method) was used. Results: The upregulation of B7-2 expression induced by WBI X-rays appeared ea r lier than that of B7-1.The study on the dose-effect relationship showed that t he ex pression of both B7-1 and B7-2 reached its peak at 0.075 Gy after WBI X-rays. Th e doses inducing a second peak of B7-1 and B7-2 upregulation were higher in th e case of WBI in comparison with in vitro irradiation. Conclusion: The results suggested that the upregulation of expression of B7 mole cules after irradiation might be an important factor involved in the enhancing e ffect of low dose radiation on immunity.关键词
X射线/小鼠腹腔巨噬细胞/B7-1/B7-2分类
医药卫生引用本文复制引用
金顺子,刘树铮..X射线对小鼠腹腔巨噬细胞表达B7-1和B7-2的影响[J].白求恩医科大学学报,2001,27(2):111-113,3.基金项目
国家自然科学基金资助项目 （）
