中国现代医学杂志2004，Vol.14Issue(3)：11-14,4.
白细胞介素18联合大剂量维生素C治疗病毒性心肌炎的实验研究
Effect of interleukin-18 combined with high-dose vitamin C on viral myocarditis
刘文春 1黄星原 2于新桥2
作者信息
- 1. 武汉大学,第一医院儿科,湖北,武汉,430060
- 2. 武汉大学,人民医院儿科,湖北,武汉,430060
- 折叠
摘要
Abstract
Objective:To study the effect of interleukin-18(IL-18)combined with high dosage vitamin C on viral myocarditis.Methods: 85 Balb/C mice infected with Coxsachievirus B3(CVB3)were divided inObjective:To four groups at random.20 cases of them were given periodically murine IL-18(0.1 microg/day.mouse)for 8 days(group IL-18); 20 case of them were given high dosage vitamin C(200 mg/kg.mouse)for 8 days(group vitamin C); 20 case of them were given IL-18 conbined with vitamin C(group combined)and 25 case of them were only given 0.2 ml normal saline(control group).The viral titer of the hearts was detected on day 5 and 8,and the myocardial inflammaObjective:Tory change was observed on pathologic pictures on day 5,8 and 15.Results:The 14-day survival rate of each treated group was higher than that of the control group(χ2 ＞ 10.46,P＜0.05).But the mice in group combined didnt survive longer than the ones in group IL-18(χ2 ＞ 0.05).Compared with group IL-18 and group vit C,the pathological integral and the viral titer of the hearts of group combined on day 5 and 8 were significantly lower(P＜0.01).Mice of group combined had less myocardial necrosis and celluar infiltration than those of the other three groups and there was significant difference(P＜0.01).Conclusions: Both IL-18 and high dos age of vitamin C can prevent virus from damaging myocardium,but the combined use of them is superior Objective:To either of them.关键词
白细胞介素18/维生素C/病毒性心肌炎/疗效Key words
viral myocarditis/interleukin-18/vitamin C/effect分类
医药卫生引用本文复制引用
刘文春,黄星原,于新桥..白细胞介素18联合大剂量维生素C治疗病毒性心肌炎的实验研究[J].中国现代医学杂志,2004,14(3):11-14,4.
