南京医科大学学报（英文版）2007，Vol.21Issue(2)：112-115,4.
The value of PAPP-A in the diagnosis and prognosis of GTD
The value of PAPP-A in the diagnosis and prognosis of GTD
Jing Fang 1Shu Wang 1Wen-li Gou1
作者信息
- 1. Department of Obstetrics and Gynecology, the First Hospital of Xi'an Jiaotong University, Xi' an 710061, China
- 折叠
摘要
Abstract
Objective: To investigate the value of PAPP-A (pregnancy assouated plasma protein-A) in the diagnosis and prognosis of gestational trophoblastic disease (GTD). Methods: The serum β-HCG (β-human chorionic gonadotropin) and PAPP-A levels of 25 normal pregnant women, 28 patients with complete hydatidiform mole and 38 patients with invasive mole were measured by enzyme linked immunosorbent assay (ELISA) during the periods of diagnosis, treatment and follow-up. Results: Compared with control group, patients with complete mole and invasive mole had higher levels of β-HCG (P ＜ 0.01 ). But there was no significant difference between the complete and invasive mole group (P ＞ 0.05). The PAPP-A level of complete mole group was significantly higher than that of control group (P ＜ 0.01). The PAPP-A level of invasive mole group was significantly higher than that of complete mole group and control group(P ＜ 0.05). In complete mole group, serum β-HCG and PAPP-A levels of the patients with malignant sequelae were significantly higher than those with benign sequelae (P ＜ 0.05). The β-HCG level had no relationship with the clinical stage of invasive mole. However, the PAPP-A level increased with clinical advancement of invasive mole. The levels of β-HCG and PAPP-A gradually decreased after evacuation in patients with complete moles, but maintained positive or even increased in patients with subsequent malignancy. Conclusion: The PAPP-A level can give us some help not only in early diagnosis of hydatidiform mole and invasive mole, but also in the prognosis of malignant sequelae.关键词
pregnancy assouated plasma protein-A/β-human chorionic gonadotropin/hydatidiform mole/invasive moleKey words
pregnancy assouated plasma protein-A/β-human chorionic gonadotropin/hydatidiform mole/invasive mole分类
医药卫生引用本文复制引用
Jing Fang,Shu Wang,Wen-li Gou..The value of PAPP-A in the diagnosis and prognosis of GTD[J].南京医科大学学报（英文版）,2007,21(2):112-115,4.
