中国病理生理杂志2009，Vol.25Issue(1)：112-117,6.
姜黄素对东茛菪碱所致小鼠记忆功能障碍的影响
Effect of curcumin on scopolamine-induced memory impairment in mice
摘要
Abstract
AIM:Scopolamine blocks cholinergic transmission and impairs learning and memory in mice．The purpose of this study was to evaluate the memory-improving properties of curcumin on scopolamine-induced memory im-pairment in mice．METHODS：The mice of memory impairment were induced by scopolamine．Step down test and Morris water maze test were used to observe the earning and memory ability in curcumin-treated ice．Biochemical assessments of AChE，MDA，and GSH-Px levels in brains were performed．RESULTS：Oral administration of curcumin ignificantly reduced the numbers of step-down rrors(P<0．05)and prolonged the step-down latency induced by scopolamine(P<0．05)．The escape latency time in mice treated with curcumin Was remarkably educed compared to that in scopolamine group by Morris water maze test(P<0．05)．After the platform was removed，the total time that the mice swam in the tar-get quadrant Was also longer in curcumin group than that in model group(P<0．05)．The data also indicated that curcumin significantly inhibited AChE ctivity(P<0．01)and prevented oxidative stress characterized by the significant reduction in MDA content and the significant increase in GSH-Px activities in the brain(P<0．01)．CONCLUSl0N：Curcumin in-duces cognitive improvement by enhancing the function of cholinergic system and its antioxidant activity．关键词
姜黄素/东莨菪碱/氧化性应激/记忆障碍Key words
Curcumin/Scopolamine/Oxidative stress/Memory disorders分类
医药卫生引用本文复制引用
董军,裘晟,陆大祥,颜亮..姜黄素对东茛菪碱所致小鼠记忆功能障碍的影响[J].中国病理生理杂志,2009,25(1):112-117,6.基金项目
Supported by Grants from Guangdong Province Natural Science Foundation(No.04010443 （）
No.06105246): Guangdong Frovlnce MedicaJ:Science Foundation(No.A2004327:No.A2000334) （No.A2004327:No.A2000334）
Guangzhou City Science and Technology Plan Foundation(No.2007J1-C01MI) （No.2007J1-C01MI）
Key Laboratory Open Foundation of Jinan University(No.51206011 （）
No.51207029) （）
