中华医学杂志（英文版）2003，Vol.116Issue(8)：1134-1136,3.
Effects of hormone replacement therapy on platelet activation in postmenopausal women
Effects of hormone replacement therapy on platelet activation in postmenopausal women
古健 1杨冬梓 1王良岸 1尹松梅 2邝健全3
作者信息
- 1. Department of Obstetrics and Gynecology Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China
- 2. Department of Hematology Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China
- 3. Department of Obstetrics and Gynecology Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China
- 折叠
摘要
Abstract
Objective To assess the effects of hormone replacement therapy (HRT) on platelet activation in postmenopausal women compared with premenopausal women. Methods The expressions of CD41 and CD62P in fifteen postmenopausal women before and after HRT were detected using flow cytometry (FCM), with fifteen premenopausal women with a mean age of 47 years as controls.Results The expressions of CD41 and CD62P in postmenopausal women were higher than those in the control group. CD62P(%), CD62P(I) and CD41 were reduced from 36.40±5.9, 37.75±5.8, and 470.11±74.0 to 27.97±5.6, 26.64±4.9, and 303.23±72.8 after six months of HRT (P<0.05). Conclusions Platelet activation in postmenopausal women was higher than in premenopausal women and was reduced significantly after six months of HRT. HRT may have a favorable effect on reduction of platelet activity.关键词
hormone replacement therapy/menopause/platelet activationKey words
hormone replacement therapy/menopause/platelet activation分类
医药卫生引用本文复制引用
古健,杨冬梓,王良岸,尹松梅,邝健全..Effects of hormone replacement therapy on platelet activation in postmenopausal women[J].中华医学杂志（英文版）,2003,116(8):1134-1136,3.
