首页|期刊导航|中国农业科学（英文版）|The Lapinized Chinese Strain Vaccine Against Classical Swine Fever Virus: A Retrospective Review Spanning Half A Century
中国农业科学（英文版）2006，Vol.5Issue(1)：1-14,14.
The Lapinized Chinese Strain Vaccine Against Classical Swine Fever Virus: A Retrospective Review Spanning Half A Century
The Lapinized Chinese Strain Vaccine Against Classical Swine Fever Virus: A Retrospective Review Spanning Half A Century
摘要
Abstract
Classical swine fever (CSF), a list A disease of Office International des Epizooties, is caused by classical swine fever virus (CSFV) belonging to the Flaviviridae family. The well-known lapinized Chinese strain of CSFV, also known as C-strain,was developed in China in the mid-1950s. In the past half a century, the vaccine has been proved to be safe and immunogenic in pigs of essentially any age. It is ofhigh efficacy, providing immunized animals with broad-spectrum,sometimes lifelong, protection, which is contributed by both cell-mediated immunity and humoral immunity, against essentially all genotypes or subgenotypes of the virus. The maternal antibodies derived from immunized sows can confer solid protection of their offspring from disease; however, they have been proved to inhibit the successful active immunization of C-strain vaccine. The complete genomes of C-strain and dozens of established or field strains have been sequenced and annotated. Recently, the reverse genetics system of C-strain has been developed, resulting in several Cstrain-derived candidate marker vaccines. Many countries manage to control or even eradicate CSF with the aid of mass vaccination with C-strain. In spite of these efforts, the eradication of the disease worldwide remains a big challenge and needs to go a long way, and provably still resorts to genetically modified C-strain vaccine. The authors present an overview of the characteristics of the vaccine, which has stood the test of half a century.关键词
classical swine fever/classical swine fever virus/C-strain vaccineKey words
classical swine fever/classical swine fever virus/C-strain vaccine分类
农业科技引用本文复制引用
QIU Hua-ji,SHEN Rong-xian,TONG Guang-zhi..The Lapinized Chinese Strain Vaccine Against Classical Swine Fever Virus: A Retrospective Review Spanning Half A Century[J].中国农业科学（英文版）,2006,5(1):1-14,14.基金项目
This work was supported by the National 973 Project,China (2005CB523202). （2005CB523202）
