中国医科大学学报2001，Vol.30Issue(2)：114-116,3.
卵巢上皮癌中nm23基因蛋白的表达及其意义
Expression of nm23 Gene Protein in Epithelial Ovarian Cancer
刘颖晖 1刘宝宜 2宋和存 3张丽红 2张忠福1
作者信息
- 1. 中国医科大学第二临床学院妇产科,
- 2. 基础医学院病理学教研室
- 3. 第一临床学院妇科病理室
- 折叠
摘要
Abstract
Objective: Our purpose was to study the expression of protein of nm23 gene in patients with epithelial ovarian carcinoma.Methods:Protein of nm23 gene was detected by immunohistochemical technique in 45 patients with epithelial ovarian cancer, 12 with borderline, and 10 with benign ovarian tumor.Results:The positive expression rate in ovarian cancer (73.3%) was significantly higher than that of the benign and borderline tumors. There was no significant correlation between the expression of nm23 gene and the histological type, grade, the existence of ascites or the size of residul after operation. However, the expression of nm23 gene protein was negatively related with the FIGO stage. The overall survival rate of the patients with positive expression of nm23 gene was much higher than that of the patients with negative expression. Conclusion:The findings suggest that nm23 gene protein might serve as a valuable and independent marker for the prognosis of ovarian cancer.关键词
卵巢上皮癌/nm23基因蛋白/预后/免疫组织化学方法分类
医药卫生引用本文复制引用
刘颖晖,刘宝宜,宋和存,张丽红,张忠福..卵巢上皮癌中nm23基因蛋白的表达及其意义[J].中国医科大学学报,2001,30(2):114-116,3.
