中华医学杂志（英文版）2003，Vol.116Issue(8)：1156-1160,5.
Identification of chromosomal imbalances in pancreatic carcinoma using comparative genomic hybridization
Identification of chromosomal imbalances in pancreatic carcinoma using comparative genomic hybridization
林谋斌 1蔡端 1骆明德2
作者信息
- 1. Department of Surgery, Huashan Hospital, Shanghai 200040, China
- 2. Department of Surgery, Xinhua Hospital, Shanghai 200045, China
- 折叠
摘要
Abstract
Objective To identify genetic abnormalities in primary pancreatic carcinoma in humans.Methods Comparative genomic hybridization (CGH) was used to investigate genomic imbalances in 27 cases of pancreatic carcinomas. Multiple deletions and gains were observed in all tumor specimens.Results Losses affecting chromosomes 9p, 17p, 4q and 6p and gains involving 8q, 7q , 3q and 1q were commonly observed.Conclusions There are multiple regions of chromosomes with changes copy number in pancreatic carcinoma. The altered chromosomal regions may contain several candidate genes which are involved in the development and progress of pancreatic carcinogenesis.关键词
carcinoma/pancreatic ductal/genomic hybridization/tumor suppressor gene/oncogeneKey words
carcinoma/pancreatic ductal/genomic hybridization/tumor suppressor gene/oncogene分类
医药卫生引用本文复制引用
林谋斌,蔡端,骆明德..Identification of chromosomal imbalances in pancreatic carcinoma using comparative genomic hybridization[J].中华医学杂志（英文版）,2003,116(8):1156-1160,5.
