首页|期刊导航|中华医学杂志（英文版）|Association of SelS mRNA expression in omental adipose tissue with Homa-IR and serum amyloid A in patients with type 2 diabetes mellitus
中华医学杂志（英文版）2008，Vol.121Issue(13)：1165-1168,4.
Association of SelS mRNA expression in omental adipose tissue with Homa-IR and serum amyloid A in patients with type 2 diabetes mellitus
Association of SelS mRNA expression in omental adipose tissue with Homa-IR and serum amyloid A in patients with type 2 diabetes mellitus
摘要
Abstract
Background Tanis was repoded as a putative receptor for serum amyloid A(SAA)involving glucose regulated protein in insulin regulated resistance.It was found to be dysregulated in diabetic rats(Psammomys obesus,Israeli sand rat)and its homologue for humans is SelS/AD-015.The present study analyzed mRNA expression of SelS in omental adipose tissue biopsies from patients with type 2 diabetes mellitus (T2DM),and age-and weight-matched nondiabetic patients,the relationship of SelS mRNA with Homa-IR and serum SAA level.Methods Human omental adipose tissues from ten cases of type 2 diabetic patients and twelve cases of nondiabetic individuals were analyzed for the expression level of SelS mRNA by semiquantitative polymerase chain reaction(PCR),Homa-IR estimated by standard formula and SM level by enzyme-linked immunosorbent assay(ELISA).Results SelS mRNA expression.Homa-IR and serum SAA were higher in T2DM sufferers than in nondiabeUc control group.SelS mRNA level was positively correlated with Homa-IR and SAA level in each group.Conclusions SelS protein may be involved in insulin resistarice;in Chinese with T2DM by acting as the SAA receptor,thus playing an important role in the development of T2DM and atherosclerosis.关键词
tanis/SelS/serum amyloid A/insulin resistance/type 2 diabetes mellitusKey words
tanis/SelS/serum amyloid A/insulin resistance/type 2 diabetes mellitus分类
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DU Jian-ling,SUN Chang-kai,L(U) Bo,MEN Li-li,YAO Jun-jie,AN Li-jia,SONG Gui-rong..Association of SelS mRNA expression in omental adipose tissue with Homa-IR and serum amyloid A in patients with type 2 diabetes mellitus[J].中华医学杂志（英文版）,2008,121(13):1165-1168,4.基金项目
This study was supported by grants from National Natural Science Foundation of China(No.30670649,No.30470682),National Key Research Project for the Tenth Five Year Plan(No.2001BA702801),and Key Research Project of Liaoning Province Bureau of Science and Technology(No.2002225003-6). （No.30670649,No.30470682）
