中国组织工程研究与临床康复2008，Vol.12Issue(6)：1165-1169,5.
生物降解材料聚L-乳酸的熔融缩聚合成
Direct synthesis of biodegradable ploy L-lactic acid by melt polycondensation
舒静 1王鹏 2郑彤 3田六一 2赵宝秀2
作者信息
- 1. 大庆石油学院化学化工学院,黑龙江省大庆市 163318
- 2. 哈尔滨工业大学市政环境工程学院,绿色化学与技术研究中心,黑龙江省哈尔滨市 150090
- 3. 大庆化工研究中心,黑龙江省大庆市 163714
- 折叠
摘要
Abstract
AIM: To synthesize biodegradable poly lactic acid (PLA) through the optimization and selection of process and catalyst.METHODS: This experiment was performed at the Research Center for Green Chemistry and Technology in the School of Municipal and Environmental Engineering of Harbin Institute of Technology from February 2003 to October 2004. Biodegradable poly L-lactic acid (PLLA) was synthesis by melt polycondensation using L-lactic acid (LA) as material. Firstly, oligo L-lactic acid (OLLA) was prepared by dehydrating aqueous solution of LA without catalyst. And then, the mixture of OLLA and catalyst was heated at a certain temperature and pressure for a period of time to get the product of PLLA. The structure of PLLA was characterized by Fourier transform infrared (FTIR) spectra and 1H- nuclear magnetic resonance (1H-NMR) spectra. The polydispersity was determined by gel permeation chromatography (GPC).RESULTS: OLLA with the viscosity average molecular weight (Mη) of 6 500 g/mol was prepared by the following steps: the solution of LA without catalyst was dehydrated at 140 ℃, first at reduced pressure of 30 kPa for 2 hours, and then at 5 kPa for 4 hours. SnCl2-p-toluenesulfonic acid (TSA) system was the effective catalyst for the polycondensation of OLLA. After the mixture of OLLA and catalysts polycondensed at 165 ℃ and 5 kPA for about 8 hours, PLLA with the Mη of 65 000 g/mol was obtained by using SnCl2-TSA system as catalyst with the SnCl2 amount of 0.4wt% to OLLA and equal mol ratio of SnCl2 and TSA.CONCLUSION:PLLA with a certain practicability was obtained under the optimal process and catalyst. Oligomerization of LA played an important role on improving the molecular weight of PLLA.关键词
生物降解材料/聚乳酸/熔融缩聚/乳酸/催化体系/组织工程分类
医药卫生引用本文复制引用
舒静,王鹏,郑彤,田六一,赵宝秀..生物降解材料聚L-乳酸的熔融缩聚合成[J].中国组织工程研究与临床康复,2008,12(6):1165-1169,5.
