中国临床康复2004，Vol.8Issue(6)：1170-1172,3.
热矿泥浴对大鼠佐剂性关节炎的作用及机制
Therapeutic effect and mechanism of thermal mineral mud-bath against adjuvant-induced arthritis in rats
林继红 1杜云娇 2肖长虹 3顾为望 1陈育尧3
作者信息
- 1. 解放军第一军医大学实验动物中心,广东省广州市,510515
- 2. 广州市越秀区第一人民医院妇科,广东省广州市,510160
- 3. 解放军第一军医大学中医系,广东省广州市,510515
- 折叠
摘要
Abstract
AIM:To observe the therapeutic effect and mechanism of thermal mineral mud-bath(TMM) against adjuvant-induced arthritis(AIA) in rats. METHODS:Wistar rats with AIA were divided into three group randomly, treated with TMM or loess mud-bath(LM) for 19 days,respectively.The control group was treated with nothing.The arthritic scores were observed constantly until the 30th day,then the specimen of blood and joints was obtained.The serum tumor necrosis factor α (TNF α )were measured by ELISA, the histopathology of the inflamed ankle were observed,and the expression of matrix metalloproteinase 1(MMP-1) mRNA and intercellular adhesion molecule 1(ICAM-1) mRNA in the synovium and cartilage were detected using in situ hybridization. RESULTS:TMM significantly decreased the severity of arthritis,including arthritic scores,synovium cells proliferation and cartilage erosion in histopathology.Besides,TMM clearly deduced the content of serum TNF α and suppressed the expressions of MMP-1 mRNA in synovium cells and chondrocytes as well as ICAM-1 mRNA in chondrocytes.Meanwhile,LM also suppressed the expression of ICAM-1 mRNA in chondrocytes. CONCLUSION:TMM significantly inhibited adjuvant-induced arthritis in rats, with suppression of serum TNF α production and the MMP-1 and ICAM-1 mRNA expression in synovium and cartilage. This therapeutic effect attributed to the colligation of physical chemical and biological effects from the thermal mineral mud-bath. 关键词
关节炎,佐剂性/泥疗法/肿瘤坏死因子/金属蛋白酶类分类
医药卫生引用本文复制引用
林继红,杜云娇,肖长虹,顾为望,陈育尧..热矿泥浴对大鼠佐剂性关节炎的作用及机制[J].中国临床康复,2004,8(6):1170-1172,3.
