中华医学杂志（英文版）2001，Vol.114Issue(11)：1171-1175,5.
加用1,6-二磷酸果糖的全肠外营养对感染动物及危重病人的支持效果
Fructose-1,6-diphosphate-added total parenteral nutrition in septic animals and stressed patients
舒志军 1黎介寿2
作者信息
- 1. 上海市中西医结合医院普外科,上海,200082
- 2. 南京军区南京总医院普外科,南京,210002
- 折叠
摘要
Abstract
Objective To investigate the roles of fructose-1,6-diphosphate(FDP)-added total parenteral nutrition
(TPN)in septic animals and stressed patients.Methods Thirteen adult dogs were randomly assigned to one of two study groups 6 hours after the induction of severe intra-abdominal infection.Group TPN(n =6)received 70 kcal· kg-1· d-1 of nonprotein calorie(NPC)and 0.56 g· kg-1· d-1 of nitrogen.1 g/kg of FDP was also infused to the animals in group TPN + FDP(n = 7)everyday.In the clinical study,the control group received routine TPN,while the study group(n = 16)was treated with TPN plus FDP(5 g,two times a day)for 7 days.Results In dogs with TPN support,plasma ATP levels were not changed significantly,while the value in the TPN + FDP group increased significantly from 0.18 μmol/L to 0.46 μmol/L at 24 h and 0.51 μmol/L at 48 h(P ＜ 0.01).Muscular ATP increased markedly in the TPN + FDP group.Muscular creatine phosphate alues were not significantly changed in the TPN group,but the values increased in the TPN + FDP group from 4.06 μmol/g·wt at the beginning to 4.93 μmol/g· wt at 24 h and 5.60 μmol/g·wt at 48 h(P ＜ 0.05),with a cytochrome oxidase increase in immunohistochemistry stain.In the clinical study,plasma ATP levels increased and urinary 3-methylhistidine production significantly decreased with an improved value for positive accumulative nitrogen balance in the FDP-infused group.Conclusion Our results suggest that total parenteral nutrition support with the supplement of fructose-1,6-diphosphate has a positive role in body energy production and protein metabolism in septic animals and stressed patients.关键词
肠外营养/1,6-二磷酸果糖/感染/应激Key words
parenteral nutrition/fructose-1,6-diphosphate/sepsis/stress分类
医药卫生引用本文复制引用
舒志军,黎介寿..加用1,6-二磷酸果糖的全肠外营养对感染动物及危重病人的支持效果[J].中华医学杂志（英文版）,2001,114(11):1171-1175,5.
