白求恩医科大学学报2001，Vol.27Issue(2)：117-118,2.
大鼠β2-糖蛋白Ⅰ的氧化修饰
Oxidative modification of rat β2-glycoprotein Ⅰ
摘要
Abstract
Objective:To investigate oxidative modification of β2-glycoprotein Ⅰ in vit ro.Methods:Rat β2-glycoprotein Ⅰ was purified and characterized,then oxidize d by hypoxanthine plus xanthine oxidase as a supreroxide free radical generating system;carbonl groups of β2-glycoprotein Ⅰ were detected by the reaction w ith 2,4-dinitrophenylhudrazine.Results:There was a significant increase of carbonyl groups formation in β2- glycoprotein Ⅰ oxidized in comparison with native β2-glycoprotein Ⅰ (P <0.05). Conclusion:Carbonyl groups have been formed in vitro on rat β2-glycoprotein Ⅰ after oxidative modification using hypoxanthine plus xanthine oxidase system.关键词
β2-糖蛋白Ⅰ/氧化修饰/黄嘌呤氧化酶分类
医药卫生引用本文复制引用
时彤,王雪丽,曲立科,杨翰仪..大鼠β2-糖蛋白Ⅰ的氧化修饰[J].白求恩医科大学学报,2001,27(2):117-118,2.基金项目
国家自然科学基金资助项目 （）
