中国免疫学杂志2001，Vol.17Issue(4)：1176-179,2.
抗CD4抗体对SEB诱导的PBMC增殖反应的抑制作用机理
The mechanism of anti-CD4 antibodies inhibitory effect on SEB-induced PBMC pro-liferation
摘要
Abstract
Objective: To explore the mechanism of anti-CD4 antibodies effect on SEB-induced proliferation of the peripheral blood mono-nuclear cells (PBMC). Methods: Using MTT method to observe anti-CD4 antibodies effect on PBMC proliferation in different conditions. Usingmorphologic, biochemisry and flow cytometer methods to detect CD4+ T cells apoptosis induced by arti-CD4 antibodies.Results: Both anti-CD4human/murine chimeric antihodies and murine McAbs could inhihit the SEB-induced PBMC proliferatuon. Anti-CD4 chimeric antibodies couldspecially induced CD4+ T cells apoptosis.Conchusion: Most important inhibitory effects of the anti-CD4 antibody appear to difrect at TCR-in-duced early activation signals, and their inhibitoryeffect of anti-CD4 chimeric antibodies is close related to the monocytes. The further cross-linking of anti-CD4 antibodies is importan for inducing CD4+ T cells apoptosis.关键词
嵌合抗体鼠源性单抗增殖抑制效应CD4+T细胞凋亡分类
医药卫生引用本文复制引用
张智红,沈关心,杨敬,朱慧芬,张悦..抗CD4抗体对SEB诱导的PBMC增殖反应的抑制作用机理[J].中国免疫学杂志,2001,17(4):1176-179,2.基金项目
本课题为国家自然科学基金资助项目(No.39370628) （No.39370628）
