现代康复2001，Vol.5Issue(3)：119-120,2.
21三体畸形儿外周血淋巴细胞中各种 21号染色体非整体细胞的发生率
Detection of aneuplodidies for chromosome－ 21 originated in vivo in human peripheral lymphocytes by using CB－ FISH method
陈建芳 1史庆华 2王伟勇 1姚辉1
作者信息
- 1. 南京医科大学脑科医院,
- 2. 南京师范大学生命科学学院
- 折叠
摘要
Abstract
Objective The CB－ FISH method for detection of aneuploidies for chromosome 21 originated in vivo in human peripheral lymphocytes has been described and characterized.Method The frequences of aneuploidies for chromosome 21 in lymphocytes in vivo of 12 trisomy 21 and 20 normal chlidren were detected by using this method.Result The frequency of trisomic cells is much higher than that of monosomics for chromosome 21 in the normal individuals,indicating that chromosome 21 non disjunction takes place more often than it's loss in vivo.The mean rate of tetrasomic cells for chromosome 21 is statistically lower than that of diploid cells in patients in vovo with trisomy 21,while chromosome 21 non disjunction is more often than it's loss in vitro.Conclusion The results imply that there is a mechanism by which cell lines were selected in vivo.关键词
21号染色体/非整倍体/嵌合体/Cytochalsin－B/荧光原位杂交分类
医药卫生引用本文复制引用
陈建芳,史庆华,王伟勇,姚辉..21三体畸形儿外周血淋巴细胞中各种 21号染色体非整体细胞的发生率[J].现代康复,2001,5(3):119-120,2.
