国际眼科杂志2007，Vol.7Issue(5)：1202-1205,4.
吡格列酮对鼠角膜碱烧伤后新生血管抑制作用的研究
Inhibitory effects of pioglitazone on alkaline burninduced corneal neovascularization in rats
张奕霞 1张明昌1
作者信息
- 1. 430022,中国湖北省武汉市,华中科技大学同济医学院附属协和医院眼科
- 折叠
摘要
Abstract
AIM: To investigate the effects of pioglitazone on corneal neovascularization(CNV)induced by alkali burnin rats and on expression of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (b-FGF).METHODS: CNV was induced by alkaline burn in rats which were then administered pioglitazone subconjunctivally.Corneal angiogenesis was evaluated and observed with a slit lamp microscope and the VEGF and b-FGF level were determined by immunohistochemistry and Western blot at different intervals.RESULTS: The CNV of the rats was shown two days after alkaline burn, and reached its highest level in 7-10 days. The mean values of the area and length of neovascularization and the VEGF and b-FGF levels in the pioglitazone-treated group were significantly lower than those in the control group at various time.CONCLUSTON: Local application of pioglitazone could remarkably inhibit CNV, probably by means of downregulation of VEGF and b-FGF expression.关键词
吡格列酮/角膜新生血管/VEGF/b-FGFKey words
pioglitazone/ CNV/ VEGF/ b-FGF分类
医药卫生引用本文复制引用
张奕霞,张明昌..吡格列酮对鼠角膜碱烧伤后新生血管抑制作用的研究[J].国际眼科杂志,2007,7(5):1202-1205,4.
