中国癌症防治杂志2009，Vol.1Issue(2)：121-123,3.
胸腺素β10在肝细胞癌中的表达及其临床意义
Expression of thymosin beta-10 gene in hepatocellular carcinoma and its clinical significance
摘要
Abstract
Objective To explore the expression of thymosin beta-10 mRNA in human HCC tissues and its clinical significance.Methods Reverse transcription polymerase chain reactions (RT-PCR) was employed to determine the expression of thymosin beta-10 mRNA in 70 cases of HCC and the adjacent liver tissues,as well as in 18 normal liver tissues.Results The expression level of thymosin beta-10 mRNA in normal liver tissue (1.30±0.53) and adjacent liver tissue (1.21±0.50) was markedly higher than that in HCC tissues (1.01±0.41,P＜0.05).The expression level of thymosin beta-10 mRNA were not significantly different between normal liver tissue and adjacent liver tissue (P＞0.05).The expression of thymosin beta-10 in HCC tissue was significantly correlated with the portal vein tumor thrombus,the number and the size of tumor,but not correlated with the clinical stage of the patients,the presence of extrahepatic metastasis,the recurrence of tumor,the level of serum alpha-fetoprotein (AFP),and the differentiation of tumor.Conclusion Thymosin beta-10 may play a role in initiation and progression of HCC.关键词
肝细胞癌/Thymosin beta-10/RT-PCRKey words
Hepatocellular carcinoma/thymosin beta-10/RT-PCR分类
医药卫生引用本文复制引用
曹骥,杨春,李丽萍,汪多平,韦薇,李瑗,欧超,苏建家,段小娴..胸腺素β10在肝细胞癌中的表达及其临床意义[J].中国癌症防治杂志,2009,1(2):121-123,3.基金项目
广西留学回国人员科学基金资助项目(桂科回0991017) （桂科回0991017）
