中国药理学通报2001，Vol.17Issue(2)：121-127,7.
ATP敏感性钾通道分子结构和功能的组织特异性研究进展
Tissue specificity in structure and function of ATP-sensitive potassium channel
朱庆磊 1汪海 2肖文彬3
作者信息
- 1. 军事医学科学院毒物药物研究所
- 2. 中国人民解放军总医院老年心血管病研究所
- 3. 军事医学科学院毒物药物研究所，
- 折叠
摘要
Abstract
ATP-sensitive potassium channels (KATP channels) play important roles in various tissues under physiological and pathophysiological conditions by coupling cell metabolic status to electrical activity. The KATP channe l is a tetrameric complex of inwardly rectified potassium (Kir) and ATP binding protein (ABP). The Kir subunits form the channel pore, whereas ABP is required for activation and regulation. Both Kir and ABP are divided into different subu nits and the various Kir and ABP subunits “mix and match” to form KATP c hannels with different pharmacological and nucleotide sensitivities. This revie w focuses on the molecular structure, physiological roles, pathophysiological an d pharmacological properties of KATP channels in different tissues.关键词
TP敏感性钾通道/分子结构/硫脲类受体/心肌/胰腺β细胞/血管平滑肌/肾/线粒体分类
医药卫生引用本文复制引用
朱庆磊,汪海,肖文彬..ATP敏感性钾通道分子结构和功能的组织特异性研究进展[J].中国药理学通报,2001,17(2):121-127,7.
