同济大学学报（医学版）2001，Vol.22Issue(3)：12-13,2.
实验性骨质疏松症大鼠模型的制备
Establishment of Experimental Animal Model of Osteoporosis
雷涛 1张秀珍 1贺铭 1谢南姿 1赵家胜 1陈亚清1
作者信息
摘要
Abstract
Objective Investigate the establishing factors of rat model of osteoporosis.Methods Wistar rats were randomly divided into three groups: the ovariectomy group, pseudo-ovariectomy group and control group. the rat model of osteoporosis was established by the ovariectomy of rat. the bone mineral density (BMD)of rats was measured with dual energy x-ray absorptimetry.Results Compared with control group, at 10 week, the BMD of ovariectomy rat was low significantly (P<0.05), at 20 week, BMD was low more significantly (P<0.01), meanwhile, the BMD of tibia and fibula was also much lower than that in control group at 20 weeks. in addition, ovariectomy rat showed the thin hair, slow-moving and slow in reaction.Conclusion 10th week maybe the best period for the establishment of rat model of osteoporosis, both the BMD measurement of whole body and tibia or fibula in rats have clinic significance.关键词
骨质疏松症/动物模型/大鼠分类
医药卫生引用本文复制引用
雷涛,张秀珍,贺铭,谢南姿,赵家胜,陈亚清..实验性骨质疏松症大鼠模型的制备[J].同济大学学报（医学版）,2001,22(3):12-13,2.
