中华医学杂志（英文版）2001，Vol.114Issue(11)：1213-1215,3.
维生素D受体基因多态性与2型糖尿病骨密度的关系
Vitamin D receptor gene polymorphism and bone mineral density in patients with type 2 diabetes mellitus
马秀萍 1景雅莉 1秦伟 1柴晓峰 1许建萍 1周铤 1杨建国1
作者信息
- 1. 北京邮电总医院内分泌科,北京,100032
- 折叠
摘要
Abstract
Objective To explore the relationship between vitamin D receptor(VDR)gene polymorphisms and bone
mineral density(BMD)in patients with type 2 diabetes mellitus(DM)and to better understand the pathogenesis of osteoporosis.Methods Ninety seven patients with type 2 DM were recruited for this study.BMD was measured by single photon absorptiometry at the lower one third of the nondominant radius and ulna.Polymorphisms of the VDR gene were analyzed by DNA amplification with polymerase chain reaction(PCR)and endonuclease digestion with Bsm Ⅰ.Results The respective frequencies of VDR genotypes were BB 18.6%,Bb 27.8% and bb 53.6%.The Z scores of the three groups were - 1.57 ± - 0.60,- 1.45 ± - 0.67 and - 1.41 ± - 0.81,respectively.Although the BMD of the Bb genotype DM patients was higher than that of BB genotype DM patients and lower than that of bb genotype DM patients,there were no significant differences.Conclusion These findings suggest a small influence of VDR gene polymorphism on the BMD of patients with type 2 DM.Further study on the value of VDR genotypes in the pathogenesis of osteoporosis in diabetes mellitus is still needed.关键词
骨质疏松 维生素D受体 骨密度 糖尿病Key words
osteoporosis/vitamin D receptor/bone mineral density/diabetes mellitus分类
医药卫生引用本文复制引用
马秀萍,景雅莉,秦伟,柴晓峰,许建萍,周铤,杨建国..维生素D受体基因多态性与2型糖尿病骨密度的关系[J].中华医学杂志（英文版）,2001,114(11):1213-1215,3.
