中国临床康复2005，Vol.9Issue(36)：122-123,2.
注意缺陷多动障碍动物模型冲动性的初步实验
Primary experiment of the impulsivity of the animal model of attention deficit hyperactivity disorder
摘要
Abstract
BACKGROUND: Abnormality exists in the process of the strengthening mechanism of attention deficit hyperactivity disorder, and impulsivity is the main manifestation of abnormal strengthening mechanism.OBJECTIVE: To probe into the change of impulsivity of animal model (spontaneously hypertensive rat, SHR) of attention deficit hyperactivity disorder.DESIGN: Non-randomized controlled, and repeated measurement design.MATERIALS: This experiment was carried out in the physiological laboratory of the Medical Department, University of Oslo, between October 1997 and January 1998. Totally 12 male rats with spontaneous hepertension and 12 male Wistar Kyoto(WKY)rats were chosen.METHODS: The experiment was conducted in the standard Campden continuous reaction test box. The experiment began at 9:00; after 2-day adaptation training, the rats were given no water for 22 hours before box training and shaping training. A long variable interval schedule was used for totally 40 days, 90minutes per day with the variable index of 180 s. The mean value of stable curve of the last 10 days of long variable interval schedule was analyzed mainly. The analyzed index was the short inter-response time (IRT) for leverpressing including reaction time 0.00 -0.33 s and reaction time 0.33-0.66 s.MAIN OUTCOME MEASURES:Short IRT for lever pressing and its changes at different stages.for short lever-pressing: SHR 0.03-0.33 s and 0.33-0.66 s were more than those of WKY rats [(172.00±44.89), (10.86±2.94) times; (90.27±28.09),divided into 3 same stages with 30 minutes in each segment. There was no obvious difference in short IRT for lever-pressing of the three stages of SHR and WKY rats (P ＞ 0.05).CONCLUSION: The impulsivity of SHR is stronger than that of WKY rats, and the reinforcement mechanism is abnormal, which is helpful for understanding the etiology and clinical therapy of attention deficit hyperactivity disorder.关键词
注意力缺损伴运动过度/大鼠,近交SHR/大鼠,近交WKY分类
医药卫生引用本文复制引用
徐通,王强虹,周翊,钱燕,胡肖伟,沈莉,Sagvolden,T..注意缺陷多动障碍动物模型冲动性的初步实验[J].中国临床康复,2005,9(36):122-123,2.基金项目
挪威国家教育基金(97-1704456) the National Eduction Foundation of Norway,No.97-1704456 （97-1704456）
