西北国防医学杂志2001，Vol.22Issue(2)：123-125,3.
血浆代用品(血定安)应用于烧伤休克复苏的实验研究
A laboratory study of plasma substitute(Gelofusion)on fluid resuscitation in burned shock
闫柏刚 1杨宗城 2黄跃生 2刘志远 2何保斌2
作者信息
- 1. 第三军医大学西南医院急救部,
- 2. 第三军医大学烧伤研究所
- 折叠
摘要
Abstract
Objective:To investigate the effects of plasma substitute(Gelofusion)on fluid resuscitation during shock in burned dogs.Methods:The dogs inflicted with 40％ TBSA Ⅲ degree scalding were randomly divided into 3 groups:thermal injury control group (C group),plasma resuscitation group(P group)and Gelofusion resuscitation group(G group).The cardiac output (CO),oxygen delivery(DO2),oxygen consumption(VO2),blood viscosity,myosin light chain 1(MLC1)and serum total protein were detected before injury and at 2,6,8,12,24,36,48 h after injury.Results:①After fluid replacement,the lever of CO,DO2 and VO2 were gradually increased,the lever of MLC1 markedly decreased,but there were no significant differences between G group and P group.②After resuscitation,blood viscosity markedly decreased,that of G group obviously lower than P group on rapid fluid replacement.③After scalding,serum total proteins were decreased,that of G group obviously lower than P group.Conclusion:In the resuscitation of burn shock,the effects of Gelofusion is similar to plasma.Gelofusion could be a fairly good plasma substitute for extensive application on the management of burn shock during the early stage.关键词
烧伤/休克/血浆代用品分类
医药卫生引用本文复制引用
闫柏刚,杨宗城,黄跃生,刘志远,何保斌..血浆代用品(血定安)应用于烧伤休克复苏的实验研究[J].西北国防医学杂志,2001,22(2):123-125,3.
