生命科学研究2001，Vol.5Issue(2)：124-129,6.
用FISH技术研究人类体外未受精卵的21号染色体非整倍体
FISH Study of Human Oocytes Failed to Fertilize in vitro Characterised with Chromosome 21 Aneuploidy
摘要
Abstract
Telomeric probe of 21qter was us ed by st andard FISH procedures to study chromosome 21 aneuploidy in the human oocytes fa iling to fertilize in vitro ,to analyze the relationship between the differe nt women′s age,IVF indications,ovarian stimulation protocols and the frequency of chromosome 21 aneuploidy . Of 54 human unfertilized oocytes, 30 were haploid (55.6%),16 were disomic(29.6%), 4 were trisomic (7.4%), 4 were nosomic (7.4%).The overall frequency of aneuploidy was 44.4%.The chromosome 21 aneuploidy was one of the factors to cause in vitro fertilization failure of human oocytes . 关键词
荧光原位杂交(FISH)/人类未受精卵/染色体21qter/非整倍体率/女性年龄/IVF指征/超排方案分类
生物科学引用本文复制引用
张群芳,卢光..用FISH技术研究人类体外未受精卵的21号染色体非整倍体[J].生命科学研究,2001,5(2):124-129,6.
