中华医学杂志（英文版）2001，Vol.114Issue(12)：1249-1251,3.
血管紧张素Ⅱ受体1基因多态性与原发性高血压的相关性研究
Association of angiotensin Ⅱ type 1 receptor gene polymorphism with
essential hypertension
蒋珍妮 1俞锋 1徐耕 1赵文胜2
作者信息
- 1. 浙江大学医学院附属第二医院心内科,杭州,310009
- 2. 浙江大学医学院附属第一医院麻醉科,杭州,310006
- 折叠
摘要
Abstract
Objective To determine whether the polymorphism A1166C in the angiotensin Ⅱ type 1 receptor (AT1R) gene is associated with essential hypertension Methods A casecontrol study was carried out using 125 hypertensive and 103 normotensive subjects The AC variant at position 1166 (A1166C) of the AT 1R gene was identified by polymerase chain reaction (PCR) and PCR/restriction fragment length polymorphism (PCR/RFLP) analysis The digestion products were separated on 2% agarose gels and visualized with ethidium bromide under ultraviolet ray Results The differences in C1166 allele frequency and in the AC genotype distribution of the AT 1R gene between the hypertensive and normotensive groups were statistically significant (C allele: 0.092 vs 0.034, χ2=6.1.86,P<0.05; AC genotype: 0.184 vs 0.068, χ2=6.654,P<0.05) Conclusion The AC genotype is associated with essential hypertension, and the C allele may be a marker for predisposition to hypertension in Chinese Han population关键词
原发性高血压/血管紧张素Ⅱ/受体/基因多态性Key words
essential hypertension/angiotensinⅡ/receptor/gene polymorphism
分类
医药卫生引用本文复制引用
蒋珍妮,俞锋,徐耕,赵文胜..血管紧张素Ⅱ受体1基因多态性与原发性高血压的相关性研究[J].中华医学杂志（英文版）,2001,114(12):1249-1251,3.
