南京医科大学学报（英文版）2008，Vol.22Issue(2)：125-129,5.
Clinical analysis of 121 patients with hypertrophic cardiomyopathy
Clinical analysis of 121 patients with hypertrophic cardiomyopathy
摘要
Abstract
Objective:Several studies have analyzed the clinical profiles of patients diagnosed with hypertrophic cardiomyopathy(HCM). We sought to identify its characteristics in a regional cohort of Nanjing and its adjacent region. Methods:Clinical profiles of 121 referred patients were collected and analyzed retrospectively. Data including family history, clinical symptoms, electrocardiography and recent echocardiography were collected. Results: The mean age of this population was 42±17 years(range from 6 to 76) at diagnosis of HCM. Most patients were male(60%). 48 patients(39.7%) has a family history, 19 had a sudden death in a first degree relative and 96(792,%) were recognized with cardiac symptoms. Left ventricular outflow obstruction (gradient≥30 mmHg at rest) was presented in 26(21.5%) patients. ECG abnormalities comprised of arrhythmia in 54(51.4%) and abnormal T wave in 72(68.6%) patients. FS were higher in female than male(P=0.001). Among younger patients(age ≤ 50 years), LVDd and LVWP were smaller in females than males(P=0.042 & 0.023 respectvely). In older patients(age ＞ 50 years), LVDs was higher in male(P= 0.016) and EF was higher in female (P=0.048). Conclusion:HCM patients in the region are almost diagnosed with the presentation of cardiac symptoms; those without any symptoms could be recognized by ECG and family screening. Most cardiac hypertrophy affects the interventricular septum. LVDd, LVWP, LVDs, FS and EF showed significant differences related to age and gender.关键词
Hypertrophic cardiomyopathy/ Arrhythmia/ Electrocardiography/ EchocardiographyKey words
Hypertrophic cardiomyopathy/ Arrhythmia/ Electrocardiography/ Echocardiography分类
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Shilu Zhao,Hengfang Wu,Jizhen Ma,Xiangjian Chen,Junhong Wang,Di Yang,Jinan Zhang..Clinical analysis of 121 patients with hypertrophic cardiomyopathy[J].南京医科大学学报（英文版）,2008,22(2):125-129,5.基金项目
This work was supported by a grant from National Natural Science Foundation of China (30570745) （30570745）
