中华医学杂志（英文版）2001，Vol.114Issue(12)：1267-1269,3.
肾组织浸润细胞在新月体肾炎患者中的分布特点及意义
The distribution and significance of renal infiltrating cells in patients with diffuse crescentic glomerulonephritis
唐政 1吴燕 1胡伟新 1姚小丹 1周红 1陈惠萍 1刘志红 1黎磊石1
作者信息
- 1. 南京大学医学院临床学院肾脏科,南京,210002
- 折叠
摘要
Abstract
Objective To study the significance and distribution of renal infiltrating cells, including monocytes (CD68+ cells), proliferative cell nuclear antigen positive cells (PCNA+ cells), CD4+ and CD8+ cells in diffuse crescent glomerulonephritis (DCGN). Methods Fifty-six patients with DCGN were studied, including 10 cases of anti-glomerular basement membrane (GBM)-type Ⅰ DCGN, 26 immune complex-type Ⅱ DCGN, and 20 cases of pauci-immune-type Ⅲ DCGN. Glomerular and interstitial infiltrates of CD68+ and PCNA+ cells, and interstitial infiltrates of CD4+ and CD8+ cells were detected by using four-layer PAP methods. Results There was a significant increase of renal infiltrating CD68+, PCNA+, CD4+ and CD8+ cells in patients with DCGN compared with that in normal controls. In patients with type Ⅰ DCGN, there was a higher number of renal infiltrating CD68+ and PCNA+ cells than that in patients with type Ⅱ and Ⅲ DCGN. A glomerular infiltrates of CD68+ and PCNA+ cells correlated with the interstitial infiltrates of CD4+ cells in type Ⅰ or Ⅲ DCGN patients. In lupus DCGN patients, the numbers of renal infiltrating CD68+ and PCNA+ cells were similar to vasculitis or type Ⅲ DCGN patients.Conclusion These findings demonstrate that the renal infiltrates of CD68+ and PCNA+ cells play an important role in patients with DCGN, that the infiltrates of CD4+ cells correlate with the infiltrates of CD68+ and PCNA+ cells may be an active marker of DCGN, and that cell-mediated immunity may contribute to crescent formation in lupus DCGN patients.关键词
新月体肾炎/免疫病理/浸润细胞Key words
CD68+ cells/PCNA+ cells * CD8+ cells/crescentic glomerulonephritis分类
医药卫生引用本文复制引用
唐政,吴燕,胡伟新,姚小丹,周红,陈惠萍,刘志红,黎磊石..肾组织浸润细胞在新月体肾炎患者中的分布特点及意义[J].中华医学杂志（英文版）,2001,114(12):1267-1269,3.
